Li Zhen-Yu, Xu Hong-Gui, Zhao Zhong-Zhen, Guo Yue-Wei
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
J Asian Nat Prod Res. 2009;11(2):153-8. doi: 10.1080/10286020802618837.
Two new Daphniphyllum alkaloids, 4,21-deacetyl-deoxyyuzurimine (1) and macropodumine L (2), together with the two known related alkaloids, have been isolated from the bark of Daphniphyllum macropodum Miq. The structures of the new compounds were elucidated on the basis of the detailed analysis of spectroscopic data, chemical method, and by comparison of the spectroscopic data with those of known compounds. Compounds 2 and 4 exhibited weak cytotoxicity against human carcinoma cell lines SMMC-7721 and HO-8910.
从交让木的树皮中分离出了两种新的交让木生物碱，4,21-去乙酰基-脱氧乌苏胺（1）和大袋鼠胺L（2），以及两种已知的相关生物碱。通过对光谱数据的详细分析、化学方法以及与已知化合物光谱数据的比较，阐明了新化合物的结构。化合物2和4对人癌细胞系SMMC-7721和HO-8910表现出微弱的细胞毒性。
