Trends Cell Biol. 1997 Sep;7(9):342-7. doi: 10.1016/S0962-8924(97)01127-6.
The GTP-binding protein Rho regulates the assembly of focal adhesions and their associated bundles of actin filaments. Two different lines of research have converged to reveal how Rho might regulate assembly of these structures. One approach has been the identification of downstream effectors of Rho, whereas the other has been the exploration of the role of contractility in promoting assembly. It is now apparent that Rho is a key regulator of actomyosin-based contractility in nonmuscle cells and that contractility, combined with adhesion to a rigid substrate, leads to the formation of both stress fibres and focal adhesions.
GTP 结合蛋白 Rho 调节焦点黏附及其相关的肌动蛋白丝束的组装。两条不同的研究途径汇聚在一起,揭示了 Rho 如何调节这些结构的组装。一种方法是鉴定 Rho 的下游效应物,另一种方法是探索收缩性在促进组装中的作用。现在很明显,Rho 是非肌肉细胞中基于肌球蛋白的收缩性的关键调节剂,并且收缩性与刚性基底的黏附相结合,导致应力纤维和焦点黏附的形成。