Di Munno O, Occhipinti G, Pontrandolfo A
Istituto di Patologia Medica, Università di Pisa.
Minerva Endocrinol. 1991 Apr-Jun;16(2):67-72.
Bone mineral content (CMO, mg/cm2) was measured at the distal radius by dual photon absorptiometry (DPA, I125, Am241) in 1.161 women (w), aged 20-87 years. Women were subdivided into different groups according to the presence and duration of menopause. For gross evaluation of spinal osteoporosis (OP), the results of spinal X-rays were graded as follows: score 0: no signs of OP; score 1: aspecific signs of OP; score 2: typical signs of OP; score 3: wedging or collapse of one or more vertebrae. Women in postmenopausal state showed significantly reduced CMO (p less than .0005) when compared to women in premenopausal state; a significant correlation was found between CMO and years since menopause (p less than .0001). Concerning the relationship between CMO and spinal score, a progressive decreases in CMO from score 0 to score 3 was present and the correlation was significant (p less than .0001). In addition, women with score 3 showed a mean CMO below the "fracture threshold", in spite of the large overlap in individual CMO values. Our data suggest that radial DPA should be maintained as a "screening" procedure for OP.
采用双光子吸收法(DPA,碘125、镅241)对1161名年龄在20至87岁的女性桡骨远端的骨矿物质含量(CMO,毫克/平方厘米)进行了测量。根据绝经的存在情况和持续时间,将女性分为不同组。对于脊柱骨质疏松症(OP)的总体评估,脊柱X线检查结果分级如下:0分:无OP迹象;1分:OP非特异性迹象;2分:OP典型迹象;3分:一个或多个椎体楔形或塌陷。与绝经前状态的女性相比,绝经后状态的女性CMO显著降低(p<0.0005);发现CMO与绝经后的年限之间存在显著相关性(p<0.0001)。关于CMO与脊柱评分的关系,从0分到3分CMO呈逐渐下降,且相关性显著(p<0.0001)。此外,尽管个体CMO值存在很大重叠,但评分为3分的女性的平均CMO低于“骨折阈值”。我们的数据表明,桡骨DPA应作为OP的“筛查”程序保留。