Mashiah Jacob, Wohl Yonit, Barnea Yoav, Schneebaum Shlomo, Gat Andrea, Misonzhnik-Bedny Faina, Brenner Sarah
Department of Dermatology, Tel Aviv Sourasky Medical Center, 6 Weizman St, 64239 Tel Aviv, Israel.
Arch Dermatol. 2007 Aug;143(8):1001-4. doi: 10.1001/archderm.143.8.1001.
To assess whether an erythematous eruption in the vicinity of or distant from a melanoma lesion might be related to the vascular endothelial growth factor, the platelet-derived endothelial cell growth factor, or both.
Biopsy specimens from 13 patients with primary melanoma, 6 of whom had erythematous eruptions and 7 who did not, were studied by immunohistochemistry for the expression of vascular endothelial growth factor and platelet-derived endothelial cell growth factor.
Vascular endothelial growth factor was positive in 3 of 6 patients (50%) with melanoma and redness (Brenner sign) and in 4 of 7 patients (57%) with melanoma without redness. Platelet-derived endothelial cell growth factor was positive in all 6 patients (100%) with melanoma and redness and in 4 of 7 patients (57%) with melanoma without redness.
Platelet-derived endothelial cell growth factor may have a part in the pathogenesis of the redness observed in patients with melanoma, called Brenner sign, by affecting vasculature function.
评估黑色素瘤病灶附近或远处的红斑疹是否可能与血管内皮生长因子、血小板衍生内皮细胞生长因子或两者都有关。
对13例原发性黑色素瘤患者的活检标本进行研究，其中6例有红斑疹，7例没有，通过免疫组织化学检测血管内皮生长因子和血小板衍生内皮细胞生长因子的表达。
6例伴有黑色素瘤及红斑（布伦纳征）的患者中有3例（50%）血管内皮生长因子呈阳性，7例无红斑的黑色素瘤患者中有4例（57%）呈阳性。6例伴有黑色素瘤及红斑的患者中血小板衍生内皮细胞生长因子均呈阳性（100%），7例无红斑的黑色素瘤患者中有4例（57%）呈阳性。
血小板衍生内皮细胞生长因子可能通过影响血管功能参与黑色素瘤患者出现的红斑（即布伦纳征）的发病机制。
