Morihara Kiyoshi, Takenaka Hideya, Morihara Toru, Kishimoto Saburo
Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
J Am Acad Dermatol. 2007 Nov;57(5 Suppl):S103-5. doi: 10.1016/j.jaad.2006.10.018.
We present a case of primary cutaneous anaplastic large cell lymphoma manifesting with widespread erythema around an ulcer. Skin biopsy from the ulcer showed CD30-positive atypical lymphocytes throughout the dermis, and immunostaining demonstrated that these cells produced vascular endothelial growth factor, a potent stimulus for angiogenesis. Skin biopsy from the erythema revealed rich neovascularization, which was probably associated with vascular endothelial growth factor.
