中性粒细胞绝对计数、杆状核计数及中性粒细胞形态学改变在预测细菌感染中的诊断价值。
The diagnostic value of absolute neutrophil count, band count and morphologic changes of neutrophils in predicting bacterial infections.
作者信息
Al-Gwaiz Layla A, Babay Hanan H
机构信息
Hematology Section, Department of Pathology, College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Kingdom of Saudi Arabia.
出版信息
Med Princ Pract. 2007;16(5):344-7. doi: 10.1159/000104806.
OBJECTIVES
To evaluate the value of neutrophil left shift parameters and neutrophil morphologic changes in diagnosing acute bacterial infections.
MATERIALS AND METHODS
Peripheral blood samples were obtained from 105 patients who had a positive culture for bacteria. Automated complete white blood cell count was performed as well as peripheral blood smear preparation. Absolute neutrophil count (ANC) and neutrophil band count were determined and the neutrophils were evaluated for morphologic changes, namely toxic granulation, vacuolation and Dohle bodies.
RESULTS
Band count was less sensitive than ANC and white blood cell count in predicting bacterial infections except in the elderly and infant population. Toxic granulation in neutrophils appeared to be as sensitive as ANC in predicting bacterial infection.
CONCLUSION
ANC and toxic granulation appear to be more sensitive than band count in predicting bacterial infections. However, band count has a greater sensitivity in infants and elderly patients.
目的
评估中性粒细胞核左移参数及中性粒细胞形态学变化在诊断急性细菌感染中的价值。
材料与方法
从105例血培养细菌阳性的患者中采集外周血样本。进行自动全血细胞计数及外周血涂片制备。测定绝对中性粒细胞计数（ANC）和中性粒细胞杆状核计数，并评估中性粒细胞的形态学变化，即中毒颗粒、空泡形成和杜勒小体。
结果
除老年和婴儿人群外，杆状核计数在预测细菌感染方面不如ANC和白细胞计数敏感。中性粒细胞中的中毒颗粒在预测细菌感染方面似乎与ANC一样敏感。
结论
在预测细菌感染方面，ANC和中毒颗粒似乎比杆状核计数更敏感。然而，杆状核计数在婴儿和老年患者中敏感性更高。
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