麻黄碱对阿片类镇痛无作用。

Lack of effect of ephedrine on opiate analgesia.

作者信息

Gordon Newton C, Heller Philip H, Levine Jon D

机构信息

Departments of Anatomy, Medicine and Oral and Maxillofacial Surgery, and Division of Neurosciences, University of California, San Francisco, CAU.S.A. Department of Emergency Medicine, Kaiser-Permanente Medical Center, Hayward, CAU.S.A.

出版信息

Pain. 1991 Oct;47(1):21-23. doi: 10.1016/0304-3959(91)90006-J.

DOI:10.1016/0304-3959(91)90006-J

PMID:1771089

Abstract

Opiate-adrenomimetic interaction was investigated by studying the effect of the adrenomimetic agent, ephedrine, on the analgesia produced by intravenous placebo and that produced by the predominantly kappa opiate agonist, pentazocine, in patients with dental postoperative pain. Ephedrine did not significantly affect the analgesia of intravenous placebo or of pentazocine. These results contrast with earlier studies demonstrating enhancement of opiate analgesia by other adrenomimetics. Further clinical studies are needed to delineate the specificity of opiate-adrenomimetic interaction.

摘要

通过研究拟肾上腺素药麻黄碱对牙科术后疼痛患者静脉注射安慰剂产生的镇痛作用以及主要作用于κ阿片受体的激动剂喷他佐辛产生的镇痛作用的影响，对阿片类药物与拟肾上腺素药的相互作用进行了研究。麻黄碱对静脉注射安慰剂或喷他佐辛的镇痛作用均无显著影响。这些结果与早期研究结果形成对比，早期研究表明其他拟肾上腺素药可增强阿片类药物的镇痛作用。需要进一步的临床研究来阐明阿片类药物与拟肾上腺素药相互作用的特异性。