可乐定增强喷他佐辛的镇痛作用。

Enhancement of pentazocine analgesia by clonidine.

作者信息

Gordon Newton C, Heller Philip H, Levine Jon D

机构信息

Departments of Anatomy, Medicine and Oral and Maxillofacial Surgery, and Division of Neurosciences, University of California, San Francisco, CAUSA Department of Emergency Medicine, Kaiser-Permanente Medical Center, Hayward, CAUSA.

出版信息

Pain. 1992 Feb;48(2):167-169. doi: 10.1016/0304-3959(92)90054-F.

DOI:10.1016/0304-3959(92)90054-F

PMID:1350340

Abstract

Opiate-adrenergic interactions were investigated by studying the effect of the selective alpha 2-adrenergic agonist, clonidine, on the analgesia produced by intravenous placebo and by the predominantly kappa-opiate agonist, pentazocine, in patients with dental postoperative pain. Clonidine did not affect the pain level when administered with intravenous placebo. When administered with pentazocine, clonidine caused a statistically significant increase in pentazocine analgesia. Comparison is made to other opiate-adrenergic interactions and possible mechanisms are discussed.

摘要

通过研究选择性α2 - 肾上腺素能激动剂可乐定对牙科术后疼痛患者静脉注射安慰剂及主要的κ-阿片类激动剂喷他佐辛所产生镇痛效果的影响，对阿片类 - 肾上腺素能相互作用进行了研究。静脉注射安慰剂时给予可乐定，不影响疼痛程度。与喷他佐辛合用时，可乐定使喷他佐辛的镇痛效果有统计学意义的增加。文中与其他阿片类 - 肾上腺素能相互作用进行了比较，并讨论了可能的机制。