Matsui H, Nishinaka K, Oda M, Niikawa H, Kubori T, Udaka F
Department of Neurology, Sumitomo Hospital, Kita-ku, Osaka, Japan.
Acta Neurol Scand. 2007 Sep;116(3):177-81. doi: 10.1111/j.1600-0404.2007.00838.x.
Dementia occurs frequently in patients with Parkinson's disease (PD). However, the nature of the dementing process remains controversial. We evaluated various cognitive functions in patients with PD, compared fractional anisotropy (FA) values between PD patients with and without dementia.
Thirty-seven consecutive patients with Hoehn-Yahr stage III or IV PD participated in this study. Patients were divided into two groups: (i) PD with dementia group (PDD) and (ii) PD without dementia group (PDND). There were 11 PDD and 26 PDND cases. Ten controls were also studied.
The PDD group showed significant FA reduction in the bilateral posterior cingulate bundles compared with PDND. FA values in the left posterior cingulate bundle showed significant correlations with many cognitive parameters.
Our results showed that the posterior cingulate areas play some important roles in the dementing process in PDD. However, as the pathological processes responsible for dementia in PD patients may be multifaceted, further studies are necessary.
痴呆在帕金森病（PD）患者中频繁发生。然而，痴呆过程的本质仍存在争议。我们评估了PD患者的各种认知功能，比较了有痴呆和无痴呆的PD患者之间的分数各向异性（FA）值。
37例连续的Hoehn-Yahr III期或IV期PD患者参与了本研究。患者被分为两组：（i）帕金森病痴呆组（PDD）和（ii）无痴呆帕金森病组（PDND）。PDD组11例，PDND组26例。还研究了10名对照者。
与PDND组相比，PDD组双侧后扣带束的FA值显著降低。左侧后扣带束的FA值与许多认知参数显著相关。
我们的结果表明，后扣带区域在PDD的痴呆过程中发挥了一些重要作用。然而，由于PD患者痴呆的病理过程可能是多方面的，因此需要进一步研究。
