Asif Nailah, Patel Apurva, Vedantam Deepanjali, Poman Devyani S, Motwani Lakshya
Research, Ras Al Khaimah (RAK) College of Medical Sciences, Ras Al Khaimah, ARE.
Research, Gujarat Medical Education & Research Society (GMERS) Medical College, Vadodara, IND.
Cureus. 2022 Jun 16;14(6):e25998. doi: 10.7759/cureus.25998. eCollection 2022 Jun.
Migraine is a neurological disorder that strongly relates to psychiatric conditions like depression. Lately, the increased prevalence of depression in migraineurs has come to attention. This article compiled various literature to explore the association between migraine and depression. Genetic overlap of various gene segments was studied, and heritability patterns were explored. Shared mechanisms such as serotonergic dysfunction, methylenetetrahydrofolate reductase (MTHFR) polymorphisms, and hormonal effects were investigated, and commonalities like comorbidities, stress, and environmental factors were analyzed. Migraine with comorbid depression (MID) affects various aspects of life and its clinical impact on migraine disability, quality of life (QOL), progression, and medication overuse was investigated. We further inspected several types of research in order to provide options on various treatment modalities. Pharmacotherapy such as antidepressants and anti-Calcitonin Gene-Related Peptide (CGRP) monoclonal antibodies like fremanezumab were studied. Alternative treatment options such as onabotulinumtoxinA (OBTA) injections, cognitive behavioral therapy (CBT), and vagal nerve stimulations (VNS) were also appraised and the efficacies of each were compared.
偏头痛是一种与抑郁症等精神疾病密切相关的神经系统疾病。最近，偏头痛患者中抑郁症患病率的上升已引起关注。本文汇编了各种文献，以探讨偏头痛与抑郁症之间的关联。研究了各种基因片段的遗传重叠，并探索了遗传模式。研究了5-羟色胺能功能障碍、亚甲基四氢叶酸还原酶（MTHFR）多态性和激素作用等共同机制，并分析了共病、压力和环境因素等共性。伴有共病性抑郁症（MID）的偏头痛会影响生活的各个方面，并研究了其对偏头痛残疾、生活质量（QOL）、病情进展和药物过度使用的临床影响。我们进一步审视了几种类型的研究，以便为各种治疗方式提供选择。研究了抗抑郁药和抗降钙素基因相关肽（CGRP）单克隆抗体（如夫瑞奈珠单抗）等药物治疗。还评估了诸如A型肉毒毒素（OBTA）注射、认知行为疗法（CBT）和迷走神经刺激（VNS）等替代治疗选择，并比较了每种方法的疗效。
