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溃疡性结肠炎的腹腔镜急诊和择期手术

Laparoscopic emergency and elective surgery for ulcerative colitis.

作者信息

Fowkes L, Krishna K, Menon A, Greenslade G L, Dixon A R

机构信息

Department of Colorectal Surgery, Frenchay Hospital, North Bristol NHS Trust, Bristol, UK.

出版信息

Colorectal Dis. 2008 May;10(4):373-8. doi: 10.1111/j.1463-1318.2007.01321.x. Epub 2007 Aug 20.

Abstract

OBJECTIVE

To analyse surgical outcomes of fulminate and medically resistant ulcerative colitis (UC) carried out laparoscopically.

METHOD

A prospective database identified 69 consecutive patients who underwent surgery for UC under the senior author over a 5-year period to April 2006.

RESULTS

Thirty-two patients (18 male patients), median BMI 26, underwent laparoscopic subtotal colectomy (LSTC): 22 acute emergencies, 10 refractory to medical therapy and unfit for restorative proctocolectomy. All were receiving iv steroids; azathioprine (7), cyclosporin (5). The median operation time was 135 min (65-280). There was one conversion. Twenty-nine patients have subsequently undergone completion proctectomy and W-pouch formation [24 patients were performed laparoscopically - laparoscopic completion proctectomy (LCP)]; widespread adhesions precluded in five patients. Twenty-six patients underwent restorative laparoscopic proctocolectomy (LRP) - one conversion. Twenty patients underwent W-pouch reconstruction via a Pfannenstiel incision. Six J-pouches were constructed and returned via the ileostomy site. Three underwent a laparoscopic pan-proctocolectomy (LPPC); one conversion. Eight patients underwent open STC. The median time to normal diet was 48 h (1-7 days) for LSTC/LCP and 36 h (1-5 days) for LRP. There were two major complications following LRP, two following LSTC, one following LCP, one following LPPC and five following open surgery. Median hospital stay was 8 days (6-72) for LSTC, 7 days (6-9) for LCP and 5 days (3-45) for LRP. There were six 30-day readmissions following laparoscopic surgery (DVT, reactive depression, ileostomy hold up (2), abdominal pain and high output ileostomy).

CONCLUSION

Laparoscopic subtotal and restorative proctocolectomies in fulminate and medically resistant UC are feasible, safe and largely predictable operations that allow for early hospital discharge. Laparoscopic colectomy facilitates subsequent proctectomy and pouch construction.

摘要

目的

分析腹腔镜下进行的暴发性及药物抵抗性溃疡性结肠炎(UC)的手术结果。

方法

一个前瞻性数据库确定了在资深作者指导下,于2006年4月前的5年期间连续接受UC手术的69例患者。

结果

32例患者(18例男性),中位体重指数为26,接受了腹腔镜次全结肠切除术(LSTC):22例为急性紧急情况,10例对药物治疗无效且不适合进行保留肛门的全结肠切除术。所有患者均接受静脉注射类固醇;7例使用硫唑嘌呤,5例使用环孢素。中位手术时间为135分钟(65 - 280分钟)。有1例中转开腹。随后29例患者接受了全直肠切除术及W形贮袋成形术[24例患者通过腹腔镜进行 - 腹腔镜全直肠切除术(LCP)];5例因广泛粘连无法进行。26例患者接受了保留肛门的腹腔镜全结肠切除术(LRP) - 1例中转开腹。20例患者通过Pfannenstiel切口进行W形贮袋重建。6例J形贮袋通过回肠造口部位构建并回纳。3例接受了腹腔镜全直肠全结肠切除术(LPPC);1例中转开腹。8例患者接受了开放性次全结肠切除术。LSTC/LCP患者恢复正常饮食的中位时间为48小时(1 - 7天),LRP患者为36小时(1 - 5天)。LRP术后有2例严重并发症,LSTC术后2例,LCP术后1例,LPPC术后1例,开放性手术后5例。LSTC患者的中位住院时间为8天(6 - 72天),LCP患者为7天(6 - 9天),LRP患者为5天(3 - 45天)。腹腔镜手术后有6例患者在30天内再次入院(深静脉血栓形成、反应性抑郁、回肠造口堵塞2例、腹痛和高流量回肠造口)。

结论

对于暴发性及药物抵抗性UC,腹腔镜次全结肠切除术及保留肛门的全结肠切除术是可行、安全且在很大程度上可预测的手术,可实现早期出院。腹腔镜结肠切除术便于后续的全直肠切除术及贮袋构建。

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