Kim Yang-Kyum, Pyo Chul-Woo, Choi Hee-Baeg, Kim Su-Yeon, Kim Tae-Yoon, Kim Tai-Gyu
Hemopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
J Dermatol Sci. 2007 Nov;48(2):133-9. doi: 10.1016/j.jdermsci.2007.06.014. Epub 2007 Aug 21.
Psoriasis is association with an overexpression of T-helper cell type 1(Th1) cytokines and relative underexpression of Th2 cytokines. The cytokine production is under genetic control, and certain allelic variants of cytokine genes are associated with higher or lower cytokine production in vitro and in vivo.
We aimed to evaluate association of cytokine genes polymorphisms with psoriasis in the Korean population.
We investigated the polymorphisms of IL-2 -330, IL-4 -590, IL-4 receptor +1902, IL-10 -1082 and -819, and IFN-gamma intron 1 in 114 psoriasis patients and 281 healthy normal controls in Korean.
IL-2 -330G and IL-4 -590C alleles significantly increased in psoriasis patients, especially late-onset group, compared to the control. The combined effect of IL-2 -330G and IL-4 -590C showed that the positive combination of IL-2 -330G and IL-4 -590C alleles were more significantly associated with the late-onset group of psoriasis patients than the controls.
These results suggest that the genetic polymorphisms of IL-2 and IL-4 genes can be susceptible to psoriasis in Korean, especially late-onset psoriasis group.
银屑病与1型辅助性T细胞（Th1）细胞因子的过度表达以及Th2细胞因子的相对低表达相关。细胞因子的产生受基因控制，细胞因子基因的某些等位基因变体在体外和体内与细胞因子产生的高低相关。
我们旨在评估韩国人群中细胞因子基因多态性与银屑病的相关性。
我们调查了114例韩国银屑病患者和281例健康正常对照者中白细胞介素-2（IL-2）-330、白细胞介素-4（IL-4）-590、白细胞介素-4受体+1902、白细胞介素-10 -1082和-819以及γ干扰素内含子1的多态性。
与对照组相比，银屑病患者尤其是晚发型组中，IL-2 -330G和IL-4 -590C等位基因显著增加。IL-2 -330G和IL-4 -590C的联合作用表明，IL-2 -330G和IL-4 -590C等位基因的阳性组合与晚发型银屑病患者组的相关性比对照组更显著。
这些结果表明，IL-2和IL-4基因的遗传多态性可能使韩国人易患银屑病，尤其是晚发型银屑病组。
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