Baran Wojciech, Szepietowski Jacek C, Mazur Grzegorz, Baran Eugeniusz
Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.
Acta Derm Venereol. 2008;88(2):113-6. doi: 10.2340/00015555-0427.
Overexpression of IL-6 has been implicated in the pathology of numerous autoimmune and chronic inflammatory diseases, including psoriasis, and relative deficiency of IL-10 in psoriatic patients seems to be important in the development of this disease. The aim of this study was to investigate the association between IL-6 and IL-10 single nucleotide polymorphisms and susceptibility to psoriasis vulgaris. DNA from 78 patients with psoriasis vulgaris and 74 healthy volunteers was investigated. IL-6 promoter gene single nucleotide polymorphisms in position -174, and IL-10 single nucleotide polymorphisms in positions -1082, -819 and -592 were evaluated by polymerase chain reaction using sequence-specific primers. No significant differences were found in the polymorphisms of IL-6 and IL-10 promoter genes between patients with psoriasis and healthy controls.
白细胞介素-6（IL-6）的过表达与包括银屑病在内的多种自身免疫性和慢性炎症性疾病的病理过程有关，银屑病患者中白细胞介素-10（IL-10）相对缺乏似乎在该疾病的发展中起重要作用。本研究的目的是调查IL-6和IL-10单核苷酸多态性与寻常型银屑病易感性之间的关联。研究了78例寻常型银屑病患者和74名健康志愿者的DNA。使用序列特异性引物通过聚合酶链反应评估IL-6启动子基因-174位点的单核苷酸多态性以及IL-10基因-1082、-819和-592位点的单核苷酸多态性。银屑病患者和健康对照之间在IL-6和IL-10启动子基因多态性方面未发现显著差异。
