Rasquin F
Service d'Ophtalmologie, Hôpital Erasme, Bruxelles.
Bull Soc Belge Ophtalmol. 2007(304):83-8.
Central serous chorioretinopathy (CSC) is a relatively frequent ocular disorder. Its pathophysiology remains however unclear. This disease typically affects young men with type A behaviour within a context of stressful events. Recently, endogenous or exogenous hypercortisolism has been associated with development, prolongation and exacerbation of CSC. Exogenous hypercortisolism has been induced by any route: intravenous, cutaneous, or nasal spray. Some clinical features such as bilaterality of lesions, an atypical form of the presentation can evoke this association. Although a few years ago glucocorticoids were still used as treatment of CSC, experimental and clinical observations suggest that they are contra-indicated in the context of CSC.
中心性浆液性脉络膜视网膜病变(CSC)是一种相对常见的眼部疾病。然而,其病理生理学仍不清楚。这种疾病通常在应激事件的背景下影响具有A型行为的年轻男性。最近,内源性或外源性皮质醇增多症与CSC的发生、病程延长和病情加重有关。外源性皮质醇增多症可通过任何途径诱发:静脉注射、皮肤给药或鼻喷雾剂。一些临床特征,如病变的双侧性、非典型的表现形式,可提示这种关联。尽管几年前糖皮质激素仍被用于治疗CSC,但实验和临床观察表明,在CSC的情况下使用它们是禁忌的。