Tittl M K, Spaide R F, Wong D, Pilotto E, Yannuzzi L A, Fisher Y L, Freund B, Guyer D R, Slakter J S, Sorenson J A
Vitreous, Retina, Macula Consultants of New York, the LuEsther T. Mertz Retina Research Laboratory, Manhattan Eye, Ear, and Throat Hospital, New York 10021, USA.
Am J Ophthalmol. 1999 Jul;128(1):63-8. doi: 10.1016/s0002-9394(99)00075-6.
To determine systemic factors associated with central serous chorioretinopathy.
In a retrospective study, 230 consecutive patients with central serous chorioretinopathy examined in a referral setting were compared with a historical gender-matched and age-matched control group of 230 patients with ocular findings who were examined in the same referral setting.
The median age of the patients was 49.8 years, and of the control subjects, 50.0 years. The male-female ratio for both groups was 2.7:1. Patients with central serous chorioretinopathy were more likely to use psychopharmacologic medications (odds ratio = 2.6; 95% confidence interval = 1.30 to 5.19; P = .0049) and corticosteroids (odds ratio = 3.17; 95% confidence interval = 1.30 to 7.70; P = .0067) and were more likely to have hypertension (odds ratio = 2.25; 95% confidence interval = 1.39 to 3.63; P = .0008) than were the control subjects.
This study identified psychopharmacologic medication use, corticosteroid use, and hypertension as factors associated with central serous chorioretinopathy. These findings reinforce the concept that stress and adaptations to stress play a role in this disorder. The findings of possible associations between central serous chorioretinopathy and both hypertension and corticosteroid usage suggest that these modifiable factors may influence morbidity of central serous chorioretinopathy.
确定与中心性浆液性脉络膜视网膜病变相关的全身因素。
在一项回顾性研究中，将在转诊机构接受检查的230例连续性中心性浆液性脉络膜视网膜病变患者与在同一转诊机构接受检查的230例有眼部检查结果、按性别和年龄匹配的历史对照组患者进行比较。
患者的中位年龄为49.8岁，对照组为50.0岁。两组的男女比例均为2.7:1。与对照组相比，中心性浆液性脉络膜视网膜病变患者更有可能使用精神类药物（比值比=2.6；95%置信区间=1.30至5.19；P=0.0049）和皮质类固醇（比值比=3.17；95%置信区间=1.30至7.70；P=0.0067），且更有可能患有高血压（比值比=2.25；95%置信区间=1.39至3.63；P=0.0008）。
本研究确定精神类药物使用、皮质类固醇使用和高血压为与中心性浆液性脉络膜视网膜病变相关的因素。这些发现强化了应激及对应激的适应在该疾病中起作用的概念。中心性浆液性脉络膜视网膜病变与高血压和皮质类固醇使用之间可能存在关联的发现表明，这些可改变的因素可能影响中心性浆液性脉络膜视网膜病变的发病率。
