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[人工基因组的合成作为合成生物学的基础]

[Synthesis of artifical genome as the basis of synthetic biology].

作者信息

Rad'ko S P, Il'ina A P, Bodoev N V, Archakov A I

出版信息

Biomed Khim. 2007 May-Jun;53(3):237-48.

Abstract

Recent achievements in the whole-genome sequencing especially viral and bacterial ones, together with the development of methods of bioinformatics and molecular biology, have created preconditions for transition from synthesis of genes to assembly of the whole genomes from chemically synthesized blocks, oligonucleotides. The creation of artificial genomes and artificial cells, will undoubtedly render huge influence on a deepening of knowledge of mechanisms of functioning of living systems at a cellular level, on a way of origin and evolution of life, and also on biotechnology of the future, and will generate preconditions for the further development of synthetic biology and nanobiotechnology.

摘要

全基因组测序,尤其是病毒和细菌基因组测序的最新成果,以及生物信息学和分子生物学方法的发展,为从基因合成过渡到利用化学合成的片段(寡核苷酸)组装整个基因组创造了前提条件。人工基因组和人工细胞的创建,无疑将对深入了解细胞水平上生命系统的运作机制、生命的起源和进化方式以及未来的生物技术产生巨大影响,并为合成生物学和纳米生物技术的进一步发展创造前提条件。

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