[通过骨髓环钻活检标本诊断淋巴增殖性疾病]

[Diagnosis of lymphoproliferative diseases by bone marrow trepanobiopsy specimens].

作者信息

Frank G A, Kaplanskaia I B, Glasko E N, Semenov E A, Roshchina L S, Korolev A V

出版信息

Arkh Patol. 2007 May-Jun;69(3):15-8.

Abstract

Based on the study of 2000 bone marrow trepanobiopsy specimens from patients with different types of lymphoproliferative diseases, the authors present the incidence and specific features of specific bone marrow lesion and the state of normal hemopoiesis and stroma. They also give data of bone marrow immunohistochemical studies using a many mono- and polyclonal antibody panels. The criteria for the differential diagnosis of reactive polyclonal lymphoid proliferation in the bone marrow that may accompany many hematological and non-hematological diseases with specific bone marrow lesion in lymphoproliferative diseases are outlined. The high diagnostic value of a study of bone marrow trepanobiopsy specimens is shown in the diagnosis of lymphoproliferative diseases.

摘要

基于对2000例不同类型淋巴增殖性疾病患者骨髓环钻活检标本的研究，作者呈现了特定骨髓病变的发生率和特征，以及正常造血和基质的状态。他们还给出了使用多种单克隆和多克隆抗体组合进行骨髓免疫组化研究的数据。概述了骨髓中反应性多克隆淋巴细胞增殖的鉴别诊断标准，这种增殖可能伴随许多血液系统和非血液系统疾病，并伴有淋巴增殖性疾病中的特定骨髓病变。骨髓环钻活检标本研究在淋巴增殖性疾病诊断中显示出很高的诊断价值。