Ben Halima Nabil, Krichen Anas, Mekki Mohamed Ali, Ben Mansour Lamia, Chabchoub Imene, Chaabouni Melek, Triki Ali, Karray Abderrahmen
Service de Pédiatrie, CHU Hédi Choker, Sfax, Tunisie.
Tunis Med. 2003 Sep;81(9):731-7.
Cow's milk allergy is defined as reproducible adverse reaction to a food protein antigen which is immune medieted. About 80 to 90 % become clinically tolerated within the first three year of live. The aim of this study is to evaluate the clinical, immunological and evolutive characteristics of the 10 % to 20 % of persistent form of cow's milk allergy.
This study included six persistent form of cow's milk allergy (2 boys and 4 girls). The provocation challenge test according to Rance recommendation, have been made from 6 months to one year.
4/6 infants with persistent cow's milk allergy have an atopic familial disease. Clinical presentation changed over time at once symptoms were preventely gastrointestinal, at the end there was an increased frequency of atopic disease (asthma: 4/6 infants)
Persistent form of cow's milk allergy are characterized by considerable importance of familial atopic disease; change in cow's milk allergy manifestations over time and more prolonged delay between cow's milk persistent consumption and manifestations of symptoms.
牛奶过敏被定义为对食物蛋白抗原的可重复出现的免疫介导的不良反应。约80%至90%的患者在生命的头三年内在临床上可耐受。本研究的目的是评估10%至20%的持续性牛奶过敏形式的临床、免疫学和演变特征。
本研究纳入了6例持续性牛奶过敏患者（2名男孩和4名女孩）。根据兰斯建议进行的激发试验在6个月至1岁之间进行。
4/6例持续性牛奶过敏婴儿患有特应性家族疾病。临床表现随时间变化，起初症状主要是胃肠道症状，最后特应性疾病（哮喘：4/6例婴儿）的发生率增加。
持续性牛奶过敏形式的特征是家族性特应性疾病相当重要；牛奶过敏表现随时间变化，以及牛奶持续摄入与症状表现之间的延迟更长。
