Eigenmann Philippe A
Department of Pediatrics, University Hospital of Geneva, Geneva, Switzerland.
Pediatr Allergy Immunol. 2007 May;18(3):265-71. doi: 10.1111/j.1399-3038.2006.00528.x.
Childhood cow's milk allergy is a diagnosis encompassing various syndromes. Antigen-immunoglobulin E (IgE) antibody interaction is classically involved in mast cell degranulation in IgE-mediated food allergy, while non-IgE mediated cow's milk allergy is mostly mediated by cellular mechanisms. The diagnosis of cow's milk allergy largely relies on a good knowledge of the clinical expression of the disease. In this educational review series, we describe three cases of cow's milk allergy, first a 7-yr-old girl with persisting IgE-mediated cow's milk allergy, second a 8-month-old boy with cow's milk induced flares of atopic dermatitis, and third a 6-yr-old boy with sheep and goat milk allergy, in the absence of cow's milk allergy. The cases are discussed and summarized with more general recommendations for the clinical management of cow's milk allergy.
儿童牛奶过敏是一种涵盖多种综合征的诊断。在IgE介导的食物过敏中，抗原-免疫球蛋白E（IgE）抗体相互作用经典地参与肥大细胞脱颗粒，而非IgE介导的牛奶过敏大多由细胞机制介导。牛奶过敏的诊断很大程度上依赖于对该疾病临床表现的充分了解。在这个教育性综述系列中，我们描述了三例牛奶过敏病例，第一例是一名7岁女孩患有持续性IgE介导的牛奶过敏，第二例是一名8个月大男孩因牛奶诱发特应性皮炎发作，第三例是一名6岁男孩对绵羊奶和山羊奶过敏，但不存在牛奶过敏。文中对这些病例进行了讨论，并总结了针对牛奶过敏临床管理的更一般性建议。
