Ghosh S, Azhahianambi P, Yadav M P
Entomology Laboratory, Division of Parasitology, Indian Veterinary Research Institute, Izatnagar, India.
J Vector Borne Dis. 2007 Jun;44(2):79-89.
Ticks are distributed worldwide and significantly impact human and animal health. Due to severe problems associated with the continuous use of acaricides on animals, integrated tick management is recommended. Increasing public health concern over the tick-borne diseases demands the strategic control of ticks on animals that transmit diseases to human beings. Immunological control of tick vector of Kyasanur Forest Disease (KFD) on cattle and other wild reservoir hosts is one of the possible alternative strategy for reducing the transmission of KFD to man. Chemical-vaccine synergies have been demonstrated and a combination of chemical and vaccine for tick and tick-borne disease control has been identified as a sustainable option. Studies have suggested the possibility of vaccine strategies directed towards both tick control and transmission of pathogens. Besides tick vaccine, use of endosymbionts, which are essential for the survival of arthropod hosts, for the control of tick vectors will be one of the targeted areas of research in near future. India with huge natural resources of herbs and other medicinal plants, the possibilities of developing herbal acaricides is discussed. The future of research directed towards target identification is exciting because of new and emerging technologies for gene discovery and vaccine formulation.
蜱虫分布于全球,对人类和动物健康有重大影响。由于在动物身上持续使用杀螨剂存在严重问题,因此建议采用综合蜱虫管理方法。公众对蜱传疾病的健康关注度不断提高,这就需要对能将疾病传播给人类的动物身上的蜱虫进行战略控制。对牛和其他野生宿主进行卡亚努尔森林病(KFD)蜱媒的免疫控制是减少KFD向人类传播的一种可能的替代策略。化学疫苗协同作用已得到证实,化学药物与疫苗联合用于蜱虫及蜱传疾病控制已被确定为一种可持续的选择。研究表明了针对蜱虫控制和病原体传播的疫苗策略的可能性。除了蜱虫疫苗,利用对节肢动物宿主生存至关重要的内共生菌来控制蜱虫媒介将是近期研究的目标领域之一。印度拥有丰富的草药和其他药用植物自然资源,文中讨论了开发草药杀螨剂的可能性。由于基因发现和疫苗配方的新技术不断涌现,针对靶点识别的研究前景令人兴奋。