FitzGerald O, Soden M, Yanni G, Robinson R, Bresnihan B
Department of Rheumatology, Beaumont Hospital, Dublin, Ireland.
Ann Rheum Dis. 1991 Nov;50(11):792-6. doi: 10.1136/ard.50.11.792.
Synovial tissues from inflamed and noninflamed knee joints of 13 patients with untreated rheumatoid arthritis were examined for vascular proliferation and morphological alteration of endothelial cells. Perivascular mononuclear cell infiltration and increased thickness of the synovial lining layer were noted in tissues from inflamed and noninflamed joints of patients with rheumatoid arthritis; vascular proliferation and morphological alteration of endothelial cells to resemble high endothelial venules were seen only in tissues from inflamed joints of patients with rheumatoid arthritis. These observations suggest that the migration of mononuclear cells from the peripheral blood to the perivascular areas and lining layer occurs before vascular proliferation and morphological alteration of endothelial cells.
对13例未经治疗的类风湿性关节炎患者发炎和未发炎膝关节的滑膜组织进行检查，以观察血管增生情况及内皮细胞的形态改变。类风湿性关节炎患者发炎和未发炎关节的组织中均可见血管周围单核细胞浸润以及滑膜衬里层增厚；仅在类风湿性关节炎患者发炎关节的组织中观察到血管增生以及内皮细胞形态改变，类似高内皮微静脉。这些观察结果表明，单核细胞从外周血迁移至血管周围区域和衬里层的过程发生在内皮细胞血管增生和形态改变之前。
