Shapiro Max A, Lewis James H
Hepatology Section, Division of Gastroenterology, Georgetown University Hospital, Georgetown University Medical Center, Washington, DC 20007, USA.
Clin Liver Dis. 2007 Aug;11(3):477-505, v. doi: 10.1016/j.cld.2007.06.003.
Drug-induced liver injury is the leading cause of acute liver failure in the United States, but the ability to ascribe hepatic injury confidently to a specific drug remains a challenging and often difficult pursuit. This article explores the ongoing challenges inherent in what is currently a clinical process of elimination made in the attempt of assigning causality in drug-induced liver injury. In particular, it points out the shortcomings and pitfalls that often limit the applicability of the causality-assessment methodologies currently in use.
药物性肝损伤是美国急性肝衰竭的主要原因，但要明确将肝损伤归因于某种特定药物，仍然是一项具有挑战性且往往困难重重的工作。本文探讨了当前在药物性肝损伤因果关系判定这一临床排除过程中固有的持续挑战。尤其指出了那些常常限制当前所用因果关系评估方法适用性的缺点和陷阱。
