Jain Mamta K
University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9113, USA.
Clin Liver Dis. 2007 Aug;11(3):615-39, vii-viii. doi: 10.1016/j.cld.2007.06.008.
Antiretroviral therapy (ART) for HIV infection frequently has been associated with elevated liver enzyme levels. Determining the cause of elevated liver enzyme levels in patients who have HIV is difficult because ART usually consists of three different drugs, patients may be taking additional hepatotoxic medications and patients who have HIV often suffer from other liver diseases. Several agents, however, are recognized as having noteworthy and specific patterns of toxicity. This article reviews the different HIV drug classes, incidence of elevated liver enzyme values by class and by individual drug, risk factors, specific toxicities, and possible mechanisms of injury.
抗逆转录病毒疗法（ART）治疗HIV感染常常与肝酶水平升高有关。确定HIV患者肝酶水平升高的原因很困难，因为ART通常由三种不同药物组成，患者可能正在服用其他肝毒性药物，且HIV患者常患有其他肝脏疾病。然而，有几种药物被认为具有值得关注的特定毒性模式。本文综述了不同的HIV药物类别、各类别及各药物导致肝酶值升高的发生率、危险因素、特定毒性以及可能的损伤机制。
