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异维A酸治疗期间的骶髂关节炎和多发性神经病。

Sacroiliitis and polyneuropathy during isotretinoin treatment.

作者信息

Eksioglu E, Oztekin F, Unlu E, Cakci A, Keyik B, Karadavut I K

机构信息

Department of Neurology, Ministry of Health, Ankara Diskapi Yildirim Beyazit Education Hospital, Ankara, Turkey.

出版信息

Clin Exp Dermatol. 2008 Mar;33(2):122-4. doi: 10.1111/j.1365-2230.2007.02532.x. Epub 2007 Aug 24.

Abstract

Isotretinoin, a medication for acne, has been reported to cause a variety of side effects on the musculoskeletal system. We present a case of sacroiliitis (a relatively uncommon feature) and sensorimotor demyelinating polyneuropathy, which has been reported previously in only a few cases during isotretinoin therapy. Clinical symptoms were improved after the withdrawal of isotretinoin and the follow-up electrophysiological study performed 2 years after the initial diagnosis of polyneuropathy showed mild improvement. Dermatologists are advised to be alert to symptoms of polyneuropathy and sacroiliitis during treatment with isotretinoin.

摘要

异维A酸是一种治疗痤疮的药物,据报道会对肌肉骨骼系统产生多种副作用。我们报告一例骶髂关节炎(一种相对不常见的特征)和感觉运动性脱髓鞘性多发性神经病,此前在异维A酸治疗期间仅有少数病例报告过。停用异维A酸后临床症状有所改善,在多发性神经病初步诊断2年后进行的随访电生理研究显示有轻度改善。建议皮肤科医生在使用异维A酸治疗期间警惕多发性神经病和骶髂关节炎的症状。

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