Institute of Dermatological Science, University of Milan, Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy.
Int J Dermatol. 2010 Mar;49(3):331-3. doi: 10.1111/j.1365-4632.2009.04334.x.
Acne fulminans is the most severe form of inflammatory acne characterized by the acute onset of inflammatory nodules and plaques, most commonly on the chest and the back. The lesions undergo rapid suppuration, leaving ragged hemorrhagic ulcers. Typically, it affects adolescent males with a history of mild to moderate acne. The affected patients often have constitutional symptoms such as fever, malaise, arthralgias, and myalgias. Leukocytosis is commonly associated. Sacroiliitis is reported in 21% of acne fulminans patients in association with arthritis and in a few cases it is reported during isotretinoin treatment, suggesting the drug triggering.
We report a case of a young male patient in whom the induction of acne fulminans by systemic isotretinoin was associated with unilateral sacroiliitis.
暴发性痤疮是最严重的炎症性痤疮形式，其特征为炎症性结节和斑块的急性发作，最常见于胸部和背部。病变迅速化脓，留下参差不齐的出血性溃疡。通常，它影响有轻度至中度痤疮病史的青少年男性。受影响的患者常有发热、不适、关节痛和肌痛等全身症状。通常伴有白细胞增多。据报道，21%的暴发性痤疮患者与关节炎有关节炎，少数病例在异维 A 酸治疗期间发生，提示药物引发。
我们报告了一例年轻男性患者，全身性异维 A 酸诱导的暴发性痤疮与单侧骶髂关节炎有关。
