Kummer Peter, Burger Martin, Schuster Maria, Rosanowski Frank, Eysholdt Ulrich, Hoppe Ulrich
Department of Phoniatrics and Pediatric Audiology, University Hospital Erlangen, Medical School, Erlangen, Germany.
Folia Phoniatr Logop. 2007;59(5):273-80. doi: 10.1159/000104466.
To compare the maturation of speech-evoked N170 components of cortical auditory evoked potentials with that of tone-evoked N1 components.
Cortical auditory evoked potentials to speech and tone stimuli were derived in 42 children from age 4 to 14 years. The N170 was derived from the difference curve of responses to monosyllabic words with initial consonant-to-vowel transitions and their intensity-equivalent noise signals.
The incidence of N1 increased from 71% below age 9 to 91% above, that of N170 tended to increase from 40 to 67% above. From age 9, adult-like morphologies of the difference waveforms were found and the time constants of N1 and N170 latency maturation were nearly identical.
The N170 component is interpreted as a response to speech-specific acoustic changes such as the consonant-vowel transition. The late appearance of N170 indicates an electrophysiological correlate of speech perception that continues to develop into adolescence. Its clinical application, however, is limited due to the low incidence of N170.
比较皮层听觉诱发电位中言语诱发N170成分与纯音诱发N1成分的成熟情况。
对42名4至14岁儿童进行言语和纯音刺激的皮层听觉诱发电位检测。N170由对具有初始辅音到元音转换的单音节词及其强度等效噪声信号的反应差异曲线得出。
N1的发生率从9岁以下的71%增加到9岁以上的91%，N170的发生率则从40%上升至67%。9岁以后，发现差异波形具有类似成人的形态，且N1和N170潜伏期成熟的时间常数几乎相同。
N170成分被解释为对言语特异性声学变化（如辅音到元音转换）的反应。N170出现较晚表明言语感知的电生理相关性持续发展至青春期。然而，由于N170的发生率较低，其临床应用受到限制。
