[八种中药材挥发油对布洛芬体外透皮吸收作用的比较]
[Comparison of the effect of eight kinds of volatile oil of Chinese material medica on percutaneous absorption of ibuprofen in vitro].
作者信息
Luo Xiao-Qing, Gu Yao-Hua, Wu Zhi-Yuan
机构信息
Suzhou Medicinal Technology College, Suzhou 215002, China.
出版信息
Zhong Yao Cai. 2007 May;30(5):571-3.
OBJECTIVE
To compare the permeation-enhancing effect of the volatile oil of eight kinds of Chinese material medica including Fructus Evodia, Radix Saposhnikoviae, Rhizoma Atractylodes lancea Radix Aucklandiae, Radix Curcuma wenyujin, Rhizoma et Radix Notopterygii, Lignum Aquilariae Resinatum, Herba Schizonepetae on the model drug of ibuprofen in order to provide theoretic foundation for the selection and application of natural penetration enhancer.
METHODS
The permeation flux of ibuprofen was determined using the penetration experiment apparatus in vitro. The content of ibuprofen was measured by HPLC.
RESULTS
All the above mentioned volatile oil showed permeation enhancing effect on ibuprofen in different degrees, and the enhancive permeation multiple was 3.46, 3.00, 2. 36, 2.32, 2.28, 2.01, 1.37 and 1.29.
CONCLUSION
All eight kinds of volatile oil can enhance the percutaneous absorption of ibuprofen in vitro, among which the volatile oil of Fructus Evodia and Radix Saposhnikoviae showed significant penetration enhancing effect.
目的
比较吴茱萸、防风、苍术、木香、莪术、羌活、沉香、荆芥8种中药材挥发油对模型药物布洛芬的促渗作用，为天然透皮促进剂的筛选与应用提供理论依据。
方法
采用体外透皮实验装置测定布洛芬的透皮速率，用高效液相色谱法测定布洛芬含量。
结果
上述挥发油均对布洛芬有不同程度的促渗作用，促渗倍数分别为3.46、3.00、2.36、2.32、2.28、2.01、1.37和1.29。
结论
8种挥发油均能促进布洛芬的体外经皮吸收，其中吴茱萸和防风挥发油的促渗作用显著。
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