[干姜、辛夷、山苍子挥发油对罗通定体外透皮的促进作用]
[Enhancing effect of volatile oils of rhizoma zingiberis, flos magnoliae and fructus litseae on permeation of rotundine in vitro].
作者信息
Cui Li-Li, Ma Yun-Shu, Han Hui-Xun
机构信息
College of Chinese Traditional Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650200, China.
出版信息
Zhong Yao Cai. 2011 May;34(5):753-7.
OBJECTIVE
To investigate the enhancing effect of volatile oils of Rhizoma Zingiberis (RZ), Flos Magnoliae (FM), Fructus Litseae (FL), Azone and pairwise combinations on the permeation of Rotundine in vitro.
METHODS
To screen out the volatile oils with the best percutaneous enhancing effect on Rotundine, a test of penetration through rats skin was conducted by using an improved Franz diffusion cell. The accumulative penetration amount of Rotundine was determined by UV and HPLC.
RESULTS
All of the 3 volatile oils had enhancing effect on Rotundine permeation. The average accumulative doses of Rotundine for 8 hours (Q8, mg/cm2) of 5% volatile oil of FL, 5% volatile oil of, RZ, 2.5% FL + 2.5% Azone were 6.0758, 6.1148, 6.5487, the enhancement ratios of 4 hours were 1.01, 1.00, 1.13 respectively.
CONCLUSION
2.5% FL + 2.5% Azone had the best effect of percutaneous enhancing on Rotundine.
目的
考察干姜（RZ）、辛夷（FM）、山苍子（FL）挥发油、氮酮及两两组合对罗通定体外透皮的促进作用。
方法
采用改良的Franz扩散池进行大鼠皮肤渗透试验，以筛选出对罗通定透皮促进作用最佳的挥发油。通过紫外分光光度法和高效液相色谱法测定罗通定的累积渗透量。
结果
3种挥发油均对罗通定透皮有促进作用。5% FL挥发油、5% RZ挥发油、2.5% FL + 2.5%氮酮作用8小时罗通定的平均累积量（Q8，mg/cm2）分别为6.0758、6.1148、6.5487，4小时的促渗倍数分别为1.01、1.00、1.13。
结论
2.5% FL + 2.5%氮酮对罗通定的透皮促进作用最佳。
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