颞叶癫痫患者胼胝体存在明显的区域萎缩。
Distinct regional atrophy in the corpus callosum of patients with temporal lobe epilepsy.
作者信息
Weber Bernd, Luders Eileen, Faber Jennifer, Richter Sabine, Quesada Carlos M, Urbach Horst, Thompson Paul M, Toga Arthur W, Elger Christian E, Helmstaedter Christoph
机构信息
Department of Epileptology, University of Bonn, Germany.
出版信息
Brain. 2007 Dec;130(Pt 12):3149-54. doi: 10.1093/brain/awm186. Epub 2007 Aug 29.
Abstract
We analysed the influence of mesial temporal lobe epilepsy on the thickness of the corpus callosum (CC) in a large sample of well-characterized patients (n = 96) and healthy controls (n = 28). In particular, we investigated whether callosal structures are differentially affected depending on the affected hemisphere and age of epilepsy onset. Overall, we observed that epilepsy is associated with a decreased thickness in posterior callosal regions. Patients with an early onset, especially patients with left onset, additionally exhibited a smaller callosal thickness in more anterior and midbody regions. These findings may reflect non-specific as well as specific effects of temporal lobe epilepsy on CC development and interhemispheric connectivity.
摘要
我们在一大群特征明确的患者（n = 96）和健康对照者（n = 28）中分析了内侧颞叶癫痫对胼胝体（CC）厚度的影响。具体而言，我们研究了胼胝体结构是否根据癫痫发作的受累半球和年龄而受到不同影响。总体而言，我们观察到癫痫与胼胝体后部区域厚度降低有关。早发性癫痫患者，尤其是左侧发病的患者，在胼胝体更靠前和中部区域的厚度也更小。这些发现可能反映了颞叶癫痫对胼胝体发育和半球间连接的非特异性以及特异性影响。
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