Neurological Institute, Epilepsy Center, Cleveland Clinic, Cleveland, OH 44195, USA.
Epilepsy Behav. 2010 Nov;19(3):376-82. doi: 10.1016/j.yebeh.2010.06.049.
We analyzed volume and diffusivity measures of the corpus callosum (CC) in patients with temporal (TLE) and frontal (FLE) lobe epilepsy in comparison with healthy subjects. On high-resolution T1-weighted scans of 18 controls and 44 patients the volumes (cm(3)) of Witelson regions (WRs) and the entire CC were measured. The apparent diffusion coefficients (ADCs, 10(-5)mm(2)s(-1)) for the entire CC and three areas of interest were measured from co-registered ADC maps. The CC of patients with TLE and FLE, corrected for total brain volume, was smaller than that of controls. Patients' ADC values were higher than those of controls. Findings were significant for WR1, WR2, and WR6, the CC regions connecting the frontal and temporal lobes. Patients with FLE had smaller WR1 and higher ADC values; in patients with TLE, the findings were similar for WR6. Atrophy and increased diffusivity in subregions of the CC connecting homotopic contralateral cortical regions indicate anatomical abnormalities extending beyond the epileptogenic zone in FLE and TLE.
我们分析了颞叶（TLE）和额叶（FLE）癫痫患者与健康受试者之间胼胝体（CC）的体积和扩散系数测量值。在 18 名对照者和 44 名患者的高分辨率 T1 加权扫描上，测量了 Witelson 区域（WRs）和整个 CC 的体积（cm³）。从配准的 ADC 图测量整个 CC 和三个感兴趣区域的表观扩散系数（ADC，10^(-5)mm²/s）。TLE 和 FLE 患者的 CC 校正总脑体积后小于对照组。患者的 ADC 值高于对照组。WR1、WR2 和 WR6 的 CC 区域连接额叶和颞叶，这些区域的发现具有统计学意义。FLE 患者的 WR1 较小，ADC 值较高；TLE 患者的 WR6 也有类似发现。连接同型对侧皮质区域的 CC 亚区的萎缩和扩散增加表明解剖学异常在 FLE 和 TLE 中超出了致痫区。
