Sigurdsson G, Nicoll A, Lewis B
Eur J Clin Invest. 1976 Mar 31;6(2):167-77. doi: 10.1111/j.1365-2362.1976.tb00508.x.
The metabolism of very low density lipoprotein-B (VLDL-B) peptide was studied in nineteen subjects with endogenous hypertriglyceridaemia (Types V, IV and IIb), three patients with heterozygous familial hyperbetalipoproteinaemia (Type IIa) and eight healthy subjects, by reinjecting autologous radioiodinated VLDL. The kinetics of VLDL-B peptide were followed. The mean turnover rate of VLDL-B peptide was significantly higher in the hypertriglyceridaemic group than in the control group but a considerable overlap in turnover rate was found between these groups. The patients with heterozygous familial hyperbetalipoproteinaemia had a normal turnover rate of VLDL-B peptide. A significant positive correlation was found between the turnover rate of VLDL-B peptide and VLDL-triglyceride concentration in the whole series. It is concluded that the underlying defect in endogenous hypertriglyceridaemia is heterogeneous. Overproduction of VLDL is a major determining factor in some patients whereas a reduced clearance is the determining factor in others.
通过重新注射自体放射性碘化极低密度脂蛋白（VLDL），对19名内源性高甘油三酯血症患者（V型、IV型和IIb型）、3名杂合子家族性高β脂蛋白血症患者（IIa型）和8名健康受试者进行了极低密度脂蛋白B（VLDL-B）肽代谢的研究。跟踪了VLDL-B肽的动力学。高甘油三酯血症组中VLDL-B肽的平均周转率显著高于对照组，但两组之间的周转率存在相当大的重叠。杂合子家族性高β脂蛋白血症患者的VLDL-B肽周转率正常。在整个系列中，VLDL-B肽的周转率与VLDL-甘油三酯浓度之间存在显著的正相关。得出的结论是，内源性高甘油三酯血症的潜在缺陷是异质性的。VLDL的过度产生是一些患者的主要决定因素，而清除率降低是其他患者的决定因素。
