Brook J G, Torsvik H, Lees R S, McCluskey M A, Feldman H A
Metabolism. 1979 Jan;28(1):4-8. doi: 10.1016/0026-0495(79)90161-6.
Low density lipoproteins (LDL) are thought to arise largely from degradation of triglyceride-rich very-low-density lipoproteins (VLDL). LDL kinetics in patients with Type IV and Type V hyperlipoproteinmia were studied and compared with normal subjects. LDL labeled in the protein moiety with 125I was used as a tracer. There was no significant difference in LDL turnover between the three groups, suggesting that a catabolic defect in VLDL degradation to LDL may exist in both Type IV and Type V hyperlipoproteinemia.
