Baron M, Gruen R, Kane J, Asnis L
Am J Psychiatry. 1985 Jun;142(6):697-701. doi: 10.1176/ajp.142.6.697.
The authors assessed the relevance of narrowly defined diagnostic criteria to genetic research in schizophrenia in the nuclear families of 84 chronic schizophrenic probands compared with families of 90 normal control probands. The morbidity risk for narrowly defined schizophrenia in first-degree relatives of patients with the narrow diagnosis was significantly higher than the control rate (3.8% versus 0.3%). The rate of chronic schizophrenia in the relatives of all schizophrenic patients was also significantly higher than the control rate (7.1% versus 0.6%), as was the rate of "spectrum" disorders (33.4% versus 11.3%). The data support the case for familial transmission of narrowly defined schizophrenia.
作者评估了狭义诊断标准与精神分裂症基因研究的相关性，研究对象为84名慢性精神分裂症先证者的核心家庭，并与90名正常对照先证者的家庭进行比较。狭义诊断的患者一级亲属中狭义精神分裂症的发病风险显著高于对照率（3.8%对0.3%）。所有精神分裂症患者亲属中慢性精神分裂症的发生率也显著高于对照率（7.1%对0.6%），“谱系”障碍的发生率也是如此（33.4%对11.3%）。这些数据支持了狭义精神分裂症家族传递的观点。
