McKenzie J M, Zakarija M
J Clin Endocrinol Metab. 1976 Apr;42(4):778-81. doi: 10.1210/jcem-42-4-778.
Several assays for thyroid-stimulating immunoglobulins in the blood in patients with Graves' disease have been described recently; depending upon the method, different names have been used and distinct entities thus implied. Using an increase in cyclic AMP in the human thyroid slice after 2 h of incubation as an index of thyroid stimulation, we identified thyroid-stimulating activity in all of an unselected series of sera from 11 patients with hyperthyroidism of Graves' disease, but long-acting thyroid stimulator, by mouse bioassay, in only three. The theory is proposed that the thyroid-stimulating immunoglobulin is probably present in all such patients; it may be seen as a polyclonal antibody to a single human antigen that has a variable cross-reaction with a corresponding thyroid antigen in the mouse and in other species.
最近已描述了几种针对格雷夫斯病患者血液中促甲状腺免疫球蛋白的检测方法；根据方法的不同，使用了不同的名称，从而暗示了不同的实体。以人甲状腺切片在孵育2小时后环磷酸腺苷的增加作为甲状腺刺激的指标，我们在一组未经挑选的11例格雷夫斯病甲亢患者的血清中均检测到了促甲状腺活性，但通过小鼠生物测定法仅在3例中检测到长效甲状腺刺激素。有人提出这样一种理论，即促甲状腺免疫球蛋白可能存在于所有此类患者中；它可能被视为针对单一人类抗原的多克隆抗体，该抗体与小鼠及其他物种中的相应甲状腺抗原具有可变的交叉反应。
