Chopra I J, Solomon D H
Annu Rev Med. 1983;34:267-81. doi: 10.1146/annurev.me.34.020183.001411.
Graves' disease is the most frequent cause of hyperthyroidism in the United States. It occurs predominantly in a genetically predisposed population. Autoimmune abnormalities constitute a major component of the disease. Immunoglobulins of patients with Graves' disease manifest a number of thyroid-targeted activities, including a thyroid-stimulating activity that is related to interaction of immunoglobulin G (IgG) with the TSH receptor. That hyperthyroidism in Graves' disease is caused by thyroid-stimulating IgGs is an attractive hypothesis but the evidence in favor of the hypothesis is still insufficient. A better alternative hypothesis is not available, however.
在美国，格雷夫斯病是甲状腺功能亢进最常见的病因。它主要发生在有遗传易感性的人群中。自身免疫异常是该疾病的主要组成部分。格雷夫斯病患者的免疫球蛋白表现出多种针对甲状腺的活性，包括一种与免疫球蛋白G（IgG）与促甲状腺激素（TSH）受体相互作用相关的甲状腺刺激活性。格雷夫斯病中的甲状腺功能亢进是由刺激甲状腺的IgG引起的，这是一个有吸引力的假说，但支持该假说的证据仍然不足。然而，目前还没有更好的替代假说。
