Nkunya M H, Weenen H, Bray D H, Mgani Q A, Mwasumbi L B
Department of Chemistry, University of Dar es Salaam, Tanzania.
Planta Med. 1991 Aug;57(4):341-3. doi: 10.1055/s-2006-960113.
Petroleum ether, dichloromethane, and methanol extracts of leaves, stem, and root bark of nine Uvaria species: U. dependens, U. faulknerae, U. kirkii, U. leptocladon, U. lucida ssp. lucida, Uvaria sp. (Pande)k U scheffleri, and U. tanzaniae were tested for their in vitro activity against the multidrug resistant K1 strain of Plasmodium falciparum. The IC50 values of the extracts varied between 5 and 500 micrograms/ml. The most active extracts were obtained from the stem and root bark of U. lucida ssp. lucida and Uvaria sp. (Pande) and the root bark of U. scheffleri, all of which had IC50 values between 5 and 9 micrograms/ml. Among the compounds isolated, uvaretin, diuvaretin, and (8',9'-dihydroxy)-3-farnesylindole were the most active (IC50 = 3.49, 4.20, and 2.86 micrograms/ml, respectively).
对九种紫玉盘属植物（即滇南紫玉盘、福氏紫玉盘、基氏紫玉盘、细枝紫玉盘、光叶紫玉盘光叶亚种、紫玉盘属某物种（潘德）、施氏紫玉盘和坦桑尼亚紫玉盘）的叶、茎和根皮的石油醚、二氯甲烷及甲醇提取物进行了体外抗恶性疟原虫多药耐药K1株活性测试。提取物的半数抑制浓度（IC50）值在5至500微克/毫升之间。活性最强的提取物来自光叶紫玉盘光叶亚种和紫玉盘属某物种（潘德）的茎和根皮以及施氏紫玉盘的根皮，其IC50值均在5至9微克/毫升之间。在分离出的化合物中，紫玉盘素、双氧紫玉盘素和（8',9'-二羟基）-3-法尼烯基吲哚活性最强（IC50分别为3.49、4.20和2.86微克/毫升）。
