Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium.
Planta Med. 2010 Feb;76(2):195-201. doi: 10.1055/s-0029-1186024. Epub 2009 Aug 3.
Medicinal plants used to treat infectious diseases in Bunda district, Tanzania, were screened for activity against Plasmodium falciparum and Human Immunodeficiency Virus Type 1 (HIV-1, IIIB strain) and Type 2 (HIV-2, ROD strain). Antiplasmodial activity was observed for the 80 % MeOH extract of Ormocarpum kirkii (root; MIC = 31.25 microg/mL), Combretum adenogonium (leaves), Euphorbia tirucalli (root), Harrisonia abyssinica (root), Rhynchosia sublobata (root), Sesbania sesban (root), Tithonia diversifolia (leaves), and Vernonia cinerascens (leaves; MIC value of 62.5 microg/mL). With regard to HIV, 80 % MeOH extracts of Barleria eranthemoides (root), Combretum adenogonium (leaves and stem bark), Elaeodedron schlechteranum (stem bark and root bark), Lannea schweinfurthii (stem bark), Terminalia mollis (stem bark and root bark), Acacia tortilis (stem bark), Ficus cycamorus (stem bark) and Indigofera colutea (shoot), as well as H2O extracts from Barleria eranthemoides (root), Combretum adenogonium (leaves and stem bark), and Terminalia mollis (stem bark and root bark) exhibited IC50 values below 10 microg/mL against HIV-1 (IIIB strain). The highest anti-HIV-1 activity value was obtained for the B. eranthemoides 80 % MeOH root extract (IC50 value 2.1 microg/mL). Only a few extracts were active against HIV-2, such as the 80 % MeOH extract from Lannea schweinfurthii (stem bark) and Elaeodedron schlechteranum (root bark), showing IC50 values < 10 microg/mL.
坦桑尼亚邦多加区用于治疗传染病的药用植物已被筛选出对疟原虫和人类免疫缺陷病毒 1 型（HIV-1，IIIb 株）和 2 型（HIV-2，ROD 株）的活性。对奥莫卡普姆·基尔基（根；MIC=31.25μg/ml）、康布雷图·阿登戈尼翁（叶）、乳木果（根）、哈里斯尼亚·阿比西尼亚（根）、里尼科西亚·苏洛巴塔（根）、塞桑比亚·塞桑布（根）、Tithonia diversifolia（叶）和 Vernonia cinerascens（叶）的 80%甲醇提取物表现出抗疟原虫活性（MIC 值为 62.5μg/ml）。关于 HIV，80%甲醇提取物巴利利亚·埃兰特海默德（根）、康布雷图·阿登戈尼翁（叶和茎皮）、埃劳多德龙·施莱赫特纳乌姆（茎皮和根皮）、兰纳·施威因弗特（茎皮）、特里尼亚·莫利斯（茎皮和根皮）、刺槐（茎皮）、榕果（茎皮）和木蓝（芽）以及巴利利亚·埃兰特海默德（根）、康布雷图·阿登戈尼翁（叶和茎皮）和特里尼亚·莫利斯（茎皮和根皮）的 H2O 提取物对 HIV-1（IIIb 株）的 IC50 值低于 10μg/ml。巴利利亚·埃兰特海默德 80%甲醇根提取物（IC50 值为 2.1μg/ml）的抗 HIV-1 活性最高。只有少数提取物对 HIV-2 有活性，如 Lannea schweinfurthii（茎皮）和 Elaeodedron schlechteranum（根皮）的 80%甲醇提取物，IC50 值<10μg/ml。
