Weenen H, Nkunya M H, Bray D H, Mwasumbi L B, Kinabo L S, Kilimali V A
Department of Chemistry, Unversity of Dar es Salaam, Tanzania.
Planta Med. 1990 Aug;56(4):368-70. doi: 10.1055/s-2006-960984.
Tanzanian medicinal plants were extracted and tested for in vitro antimalarial activity, using the multidrug resistant K1 strain of Plasmodium falciparum. Of 49 plants investigated, extracts of three plants were found to have an IC50 between 5-10 micrograms/ml, extracts of 18 other plants showed an IC50 between 10 and 50 micrograms/ml, all others were less active. The three most active extracts were obtained from the tubers of Cyperus rotundus L. (Cyperaceae), the rootbark of Hoslundia opposita Vahl. (Labiatae), and the rootbark of Lantana camara L. (Verbenaceae).
利用耐多药的恶性疟原虫K1株，对坦桑尼亚药用植物进行了提取，并测试其体外抗疟活性。在所研究的49种植物中，发现三种植物的提取物的半数抑制浓度（IC50）在5至10微克/毫升之间，另外18种植物的提取物的IC50在10至50微克/毫升之间，其他所有植物的活性较低。三种活性最高的提取物分别取自香附子（莎草科）的块茎、对叶肾茶（唇形科）的根皮以及马缨丹（马鞭草科）的根皮。
