安哥拉楝（楝科）茎皮的抗疟原虫剂。
The antiplasmodial agents of the stem bark of Entandrophragma angolense (Meliaceae).
作者信息
Bickii Jean, Tchouya Guy Raymond Feuya, Tchouankeu Jean Claude, Tsamo Etienne
机构信息
Institut de Recherches Médicales et d'Etudes des Plantes Médicinales, Laboratoire de Recherche sur le Paludisme, Yaoundé, Cameroon.
出版信息
Afr J Tradit Complement Altern Med. 2006 Nov 13;4(2):135-9.
Abstract
In the search of active principles from the stem bark of Entandrophragma angolense, we submitted the compounds isolated from the dichloromethane-methanol (1:1) extract of the stem bark to antimalarial test against chloroquine resistant strain W2 of Plasmodium falciparum malaria parasite. Only 7alpha-obacunyl acetate and a cycloartane derivative exhibited a good activity, with IC(50)s of 2 and 5.4 microg/ml respectively. Other compounds were moderately active.
摘要
在从安哥拉Entandrophragma的茎皮中寻找活性成分的过程中，我们将从该茎皮的二氯甲烷 - 甲醇（1:1）提取物中分离得到的化合物，针对恶性疟原虫氯喹抗性菌株W2进行了抗疟测试。只有7α - 乙酸奥巴库酯和一种环阿尔廷烷衍生物表现出良好的活性，其半数抑制浓度（IC50）分别为2和5.4微克/毫升。其他化合物活性中等。
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