Bickii Jean, Tchouya Guy Raymond Feuya, Tchouankeu Jean Claude, Tsamo Etienne
Institut de Recherches Médicales et d'Etudes des Plantes Médicinales, Laboratoire de Recherche sur le Paludisme, Yaoundé, Cameroon.
Afr J Tradit Complement Altern Med. 2006 Nov 13;4(2):135-9.
In the search of active principles from the stem bark of Entandrophragma angolense, we submitted the compounds isolated from the dichloromethane-methanol (1:1) extract of the stem bark to antimalarial test against chloroquine resistant strain W2 of Plasmodium falciparum malaria parasite. Only 7alpha-obacunyl acetate and a cycloartane derivative exhibited a good activity, with IC(50)s of 2 and 5.4 microg/ml respectively. Other compounds were moderately active.
在从安哥拉Entandrophragma的茎皮中寻找活性成分的过程中，我们将从该茎皮的二氯甲烷 - 甲醇（1:1）提取物中分离得到的化合物，针对恶性疟原虫氯喹抗性菌株W2进行了抗疟测试。只有7α - 乙酸奥巴库酯和一种环阿尔廷烷衍生物表现出良好的活性，其半数抑制浓度（IC50）分别为2和5.4微克/毫升。其他化合物活性中等。
