O'Callaghan A C, Koren G, Sloan I A
Department of Anaesthesia, Hospital for Sick Children, Toronto, Ontario.
Res Commun Chem Pathol Pharmacol. 1991 Dec;74(3):299-315.
The uptake of nitrous oxide (N2O) was calculated by using a new application of pharmacokinetics involving cumulative fractional expired N2O concentration at 90 percent steady state. The effect of age on N2O uptake was investigated in 33 normal children undergoing non-cardiac surgery. Uptake was also investigated in 17 children with right-to-left cardiac stunts and 18 children with left-to-right shunts undergoing corrective or palliative cardiac surgery. There was a significant correlation of N2O elimination half-life (T1/2) with age for normal children (p less than 0.001), and for children with right-to-left (p less than 0.001) or left-to-right (p = 0.05) shunts. Elimination T1/2 in children with left-to-right shunts correlated significantly with the calculated shunt fraction (p less than 0.05). By providing a useful means for comparison, this method of measuring N2O uptake permits determination of the effects of age, weight and cardiac shunts on the uptake kinetics of N2O.
通过一种新的药代动力学应用方法来计算氧化亚氮（N₂O）的摄取量，该方法涉及在90%稳态时累积的呼出N₂O分数浓度。对33名接受非心脏手术的正常儿童进行了年龄对N₂O摄取影响的研究。还对17名患有右向左心脏分流的儿童和18名患有左向右分流并接受矫正或姑息性心脏手术的儿童的N₂O摄取情况进行了研究。正常儿童的N₂O消除半衰期（T₁/₂）与年龄存在显著相关性（p<0.001），右向左分流（p<0.001）或左向右分流（p = 0.05）的儿童也是如此。左向右分流儿童的消除T₁/₂与计算出的分流分数显著相关（p<0.05）。通过提供一种有用的比较方法，这种测量N₂O摄取的方法能够确定年龄、体重和心脏分流对N₂O摄取动力学的影响。
