Salanitre E, Rackow H
Anesth Analg. 1976 Jan-Feb;55(1):95-9.
Exhaled volumes were measured in 8 children during uptake and elimination of 3 percent and 75 percent N2O, using a volume-controlled ventilator. Absorption of 75 percent N2O during induction reduced the exhaled minute volume, which fell a mean of 16 percent in the 1st or 2nd minute and returned to normal by 15 to 20 minutes. Elimination was the mirror image of uptake; the mean increase in the exhaled minute volume was 13 percent. The concentration effect during uptake was measured (3 percent versus 75 percent N2O) and the data were used to calculate a fall in alveolar volume of at least 8 percent by the 2nd minute of uptake. The type of ventilation (volume-limited, pressure-limited, or spontaneous) was seen to have a modifying role on the respiratory pattern caused by the absorbed and excreted volume of N2O.
在8名儿童吸入和排出3%和75%氧化亚氮期间，使用容量控制通气机测量呼出量。诱导期间吸入75%氧化亚氮会降低呼出分钟通气量，在第1或第2分钟平均下降16%，并在15至20分钟恢复正常。排出是吸入的镜像；呼出分钟通气量平均增加13%。测量了吸入期间的浓度效应（3%与75%氧化亚氮），并使用这些数据计算出在吸入第2分钟时肺泡容积至少下降8%。观察到通气类型（容量限制、压力限制或自主通气）对由氧化亚氮的吸收和排出量引起的呼吸模式具有调节作用。
