Xiangdong W, Ar'Rajab A, Ahrén B, Andersson R, Bengmark S
Department of Surgery, Lund University, Sweden.
Res Exp Med (Berl). 1991;191(6):429-35. doi: 10.1007/BF02576698.
We previously reported that co-transplantation of hepatocytes and islets of Langerhans in the spleen reduces the mortality rate after 90% hepatectomy in the rat. In the present study, we examined whether implantation of isolated hepatocytes into the pancreas is as efficient as co-transplantation of hepatocytes and islets in this respect. We found that cotransplantation of hepatocytes and islets into the renal subcapsule reduced the long-term (30-day) mortality rate after 90% hepatectomy from 100% to 36% (P less than 0.05) when performed the day before the hepatectomy. In contrast, there was no significant reduction of mortality when the hepatocytes were transplanted into the pancreas. The results show that a close proximity of transplanted pancreatic islets to the hepatocytes is of critical importance for the improved survival in acute liver failure.
我们之前报道过，将肝细胞和胰岛共同移植到脾脏中可降低大鼠90%肝切除术后的死亡率。在本研究中，我们检测了在这方面将分离的肝细胞植入胰腺是否与肝细胞和胰岛共同移植一样有效。我们发现，在肝切除术前一天将肝细胞和胰岛共同移植到肾被膜下，可使90%肝切除术后的长期（30天）死亡率从100%降至36%（P<0.05）。相比之下，将肝细胞移植到胰腺中时，死亡率没有显著降低。结果表明，移植的胰岛与肝细胞紧密相邻对于改善急性肝衰竭的存活率至关重要。
