Morse D E, Hooker N, Duncan H, Jensen L
Science. 1979 Apr 27;204(4391):407-10. doi: 10.1126/science.204.4391.407.
gamma-Aminobutyric acid (a simple amino acid and potent neurotransmitter in human brain and other tissues of higher animals) and certain of its congeners rapidly and synchronously induce planktonic larvae of the red abalone, Haliotis rufescens, to settle and commence behavioral and developmental metamorphosis. These naturally occurring inducers of algal origin apparently are responsible, in part, for the substrate-specific recruitment, induction of settling, and the onset of metamorphosis of abalone and other planktonic larvae upon specific algae which provide naturally favorable habitats for the young of these species in coastal waters. These observations provide a convenient experimental model for further analysis of the basic molecular mechanisms by which environmental and endogenous factors control the recruitment and development of planktonic larvae. Halogenated organic pesticides significantly interfere with larval settling, as quantified in a new bioassay based upon these findings.
γ-氨基丁酸（一种简单的氨基酸，是人类大脑及高等动物其他组织中的强效神经递质）及其某些同系物能迅速且同步地诱导红鲍（Haliotis rufescens）的浮游幼虫附着，并开始行为和发育变态。这些天然存在的藻类来源诱导物显然在一定程度上促成了底物特异性招募、附着诱导以及鲍鱼和其他浮游幼虫在特定藻类上的变态起始，这些藻类为这些物种的幼体在沿海水域提供了天然适宜的栖息地。这些观察结果为进一步分析环境和内源性因素控制浮游幼虫招募和发育的基本分子机制提供了一个便利的实验模型。如基于这些发现的一项新生物测定所量化的那样，卤代有机农药会显著干扰幼虫附着。
