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溶血与感染:它们相互关系的类别及机制

Hemolysis and infection: categories and mechanisms of their interrelationship.

作者信息

Berkowitz F E

机构信息

Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30303.

出版信息

Rev Infect Dis. 1991 Nov-Dec;13(6):1151-62. doi: 10.1093/clinids/13.6.1151.

DOI:10.1093/clinids/13.6.1151
PMID:1775848
Abstract

Different cause-and-effect relationships between hemolytic and infectious processes are categorized in a clinically useful manner as follows: infections causing hemolysis by invasion of red blood cells (RBCs), by hemolysins, or by immune mechanisms; oxidative damage to RBCs during infections; hemolysis secondary to infection-induced pathologic processes; hemolytic effects of antimicrobial therapy; and predisposition of an individual to infection caused by an underlying hemolytic disorder or therapy for that disorder. The mechanisms of these interrelationships are discussed in detail.

摘要

溶血过程与感染过程之间不同的因果关系,按照临床实用的方式可分类如下:感染通过侵入红细胞、溶血素或免疫机制导致溶血;感染期间红细胞的氧化损伤;继发于感染诱导的病理过程的溶血;抗菌治疗的溶血作用;以及个体因潜在的溶血性疾病或针对该疾病的治疗而易于感染。这些相互关系的机制将详细讨论。

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