Menei P, Fournier D, Alhayek G, Mercier P, François H, Audran M, Guy G
Service de Neurochirurgie, Centre hospitalier Régional et Universitaire, Angers.
Rev Rhum Mal Osteoartic. 1991 Oct;58(9):605-9.
Recently, it has been demonstrated that symptomatic epidural calcifications represent a complication of intradiscal injection of triamcinolone hexacetonide (Hexatrione). Out of our three cases, pathological examination showed lesions of necrosis with granulomatous inflammatory reaction and bone metaplasia. Necrosis seems to be the primary cause of calcifications so we propose to call the lesion inflammatory and necrotic granuloma. The incidence of these granulomas is unknown. They are unpredictable and appear with a mean range of a year following the intradiscal injection. The treatment is surgery if they become symptomatic.
最近，有研究表明，有症状的硬膜外钙化是椎间盘内注射己曲安奈德（曲安缩松）的一种并发症。在我们的三例病例中，病理检查显示有坏死性病变，并伴有肉芽肿性炎症反应和骨化生。坏死似乎是钙化的主要原因，因此我们建议将这种病变称为炎性坏死性肉芽肿。这些肉芽肿的发病率尚不清楚。它们不可预测，在椎间盘内注射后平均一年左右出现。如果出现症状，治疗方法是手术。
