Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, USA.
Curr Rev Musculoskelet Med. 2008 Jun;1(2):103-7. doi: 10.1007/s12178-007-9015-y.
LBP is one of the most common reasons for visiting a doctor and is the most common cause of disability under age 45.Amongst a variety of etiologies, internal disc disruption (IDD) has been postulated as an important cause of low back pain. Treating discogenic low back pain continues to be a challenge to physicians. Inflammation, either from direct chemical irritation or secondary to an autoimmune response to the nucleus pulposus has been implicated as the primary pain source. Both steroids and non-steroidal anti-inflammatory drugs have partial effectiveness in treating pain associated with inflammation. Therefore, the rationale for using intradiscal steroids is to suppress the inflammation within the disc, thereby alleviating the patient's symptoms. The goal of this article is to review the literature regarding the efficacy of intradiscal steroids to treat low back pain of discogenic origin.
下腰痛是就诊最常见的原因之一,也是 45 岁以下人群残疾的最常见原因。在诸多病因中,椎间盘内部破裂(IDD)被认为是导致下腰痛的重要原因。治疗椎间盘源性下腰痛一直是医生面临的挑战。炎症,无论是来自直接的化学刺激还是继发于对髓核的自身免疫反应,都被认为是主要的疼痛来源。甾体类药物和非甾体类抗炎药在治疗与炎症相关的疼痛方面都有一定的效果。因此,使用椎间盘内类固醇的基本原理是抑制椎间盘内的炎症,从而缓解患者的症状。本文的目的是回顾关于椎间盘内类固醇治疗椎间盘源性下腰痛的疗效的文献。