Kontogiorgi Marina, Floros Ioannis, Koroneos Apostolos, Vamvouka Chrysanthi, Paniara Olga, Roussos Charis, Routsi Christina
Critical Care Department, Medical School of Athens University, Evangelismos Hospital, Athens, Greece.
Department of Pathology, Evangelismos Hospital, Athens, Greece.
J Med Microbiol. 2007 Sep;56(Pt 9):1243-1245. doi: 10.1099/jmm.0.46993-0.
Zygomycosis, a relatively uncommon infection, usually occurs among immunocompromised individuals. It has been reported only rarely in trauma patients. A fatal case is reported of pulmonary and rapidly progressive cutaneous zygomycosis in a young, otherwise healthy farmer, with multiple bone fractures, wounds and soft tissue injuries after an accident with an agricultural machine in the field. Rhizopus spp. was isolated from both cultures of bronchial washings and wound samples. The diagnosis was confirmed by histopathological examination of tissue specimens from a large wound. Despite systemic antifungal therapy and surgical debridement, the patient's condition deteriorated and he died from refractory septic shock.
接合菌病是一种相对罕见的感染，通常发生在免疫功能低下的个体中。在创伤患者中仅有极少病例报道。本文报告了一例致命的接合菌病病例，患者为一名年轻且原本健康的农民，在田间遭遇农业机械事故后出现多处骨折、伤口及软组织损伤，随后发生肺部及快速进展的皮肤接合菌病。从支气管灌洗物和伤口样本培养物中均分离出根霉属真菌。通过对一个大伤口的组织标本进行组织病理学检查确诊。尽管进行了全身抗真菌治疗和手术清创，患者病情仍恶化，最终死于难治性感染性休克。
