McKinney J D, Heintz N
Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021.
Trends Biochem Sci. 1991 Nov;16(11):430-5. doi: 10.1016/0968-0004(91)90170-z.
Cell-cycle-regulated transcription is a characteristic feature of complex cell cycles in organisms as divergent as yeasts and humans. Increasing evidence suggests that transcriptional regulation may control key events in the eukaryotic cell cycle. In this review we will address the mechanisms that may regulate transcription during the cell cycle and the roles which periodic transcription may serve in the control of cell cycle progression.
细胞周期调控转录是酵母和人类等差异极大的生物体中复杂细胞周期的一个特征。越来越多的证据表明,转录调控可能控制真核细胞周期中的关键事件。在本综述中,我们将探讨细胞周期中可能调控转录的机制,以及周期性转录在控制细胞周期进程中可能发挥的作用。