Jones A W, Sternebring B
Department of Forensic Toxicology, National Institute of Forensic Medicine, University Hospital, Linköping, Sweden.
Alcohol Alcohol. 1992 Nov;27(6):641-7.
We investigated the kinetics of ethanol and methanol in 20 dependent alcoholics (16 men and four women) during the first 24 hr after admission to hospital for detoxification. The blood-ethanol concentration (BEC) on admission ranged from 238 to 489 mg/dl (mean 386 mg/dl). The mean rate of ethanol disappearance from the blood was 23 mg/dl/hr with a spread from 13 to 36 mg/dl/hr. The concentrations of methanol in blood at the start of detoxification ranged from 0.16 to 2.8 mg/dl (mean 1.15 mg/dl) and these levels remained more or less unchanged until the BEC had dropped below 30 mg/dl. The concentrations of ethanol and methanol in blood at the start of detoxification were not correlated (r = 0.032, P > 0.05). The results of this study do not support the notion that the metabolism of methanol in chronic alcoholics proceeds independently of the prevailing BEC. We found a three-fold difference in the rate of disappearance of ethanol from blood in alcohol-dependent subjects.
我们对20名依赖酒精者（16名男性和4名女性）在入院接受戒酒治疗的头24小时内乙醇和甲醇的动力学进行了研究。入院时血液乙醇浓度（BEC）范围为238至489毫克/分升（平均386毫克/分升）。血液中乙醇消失的平均速率为23毫克/分升/小时，范围为13至36毫克/分升/小时。戒酒开始时血液中甲醇浓度范围为0.16至2.8毫克/分升（平均1.15毫克/分升），在BEC降至30毫克/分升以下之前，这些水平基本保持不变。戒酒开始时血液中乙醇和甲醇的浓度无相关性（r = 0.032，P>0.05）。本研究结果不支持慢性酒精中毒者体内甲醇代谢独立于当时BEC的观点。我们发现酒精依赖者血液中乙醇消失速率存在三倍的差异。
