通过调节肾上腺素能受体逆转心脏重塑：心力衰竭治疗的新前沿
Reversal of cardiac remodeling by modulation of adrenergic receptors: a new frontier in heart failure.
作者信息
Perrino Cinzia, Rockman Howard A
机构信息
Division of Cardiology, Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Naples, Italy.
出版信息
Curr Opin Cardiol. 2007 Sep;22(5):443-9. doi: 10.1097/HCO.0b013e3282294d72.
PURPOSE OF REVIEW
Heart failure is a common clinical syndrome, and despite intensive medical therapy it remains a leading cause of global morbidity and mortality. Pathological stimuli promote a general remodeling process in the heart.
RECENT FINDINGS
Recent animal studies have highlighted very promising novel therapeutic possibilities, based on the regulation of adrenergic receptor function, and novel signaling pathways are being discovered that could be relevant for future molecular approaches.
SUMMARY
This review highlights some of the novel approaches to reverse pathological remodeling and improve cardiac dysfunction, placing emphasis on strategies targeting the adrenergic receptors.
综述目的
心力衰竭是一种常见的临床综合征，尽管进行了强化药物治疗，但它仍然是全球发病和死亡的主要原因。病理刺激会促进心脏的一般重塑过程。
最新发现
最近的动物研究突出了基于肾上腺素能受体功能调节的非常有前景的新型治疗可能性，并且正在发现可能与未来分子方法相关的新信号通路。
总结
本综述重点介绍了一些逆转病理重塑和改善心脏功能障碍的新方法，重点是针对肾上腺素能受体的策略。
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